Assay Detail
ADMET
CHEMBL5240233
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Inhibition of recombinant human CYP1B1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design and Synthesis of Novel <i>N</i>-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 7.63 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279681 | — | — | 1 | 10.05 |
| CHEMBL5287897 | — | — | 1 | 9.26 |
| CHEMBL5290149 | — | — | 1 | 8.92 |
| CHEMBL5280516 | — | — | 1 | 8.75 |
| CHEMBL5289888 | — | — | 1 | 8.41 |
| CHEMBL5280415 | — | — | 1 | 8.30 |
| CHEMBL5283668 | — | — | 1 | 8.22 |
| CHEMBL5289447 | — | — | 1 | 8.20 |
| CHEMBL5272094 | — | — | 1 | 8.19 |
| CHEMBL5282966 | — | — | 1 | 8.18 |
| CHEMBL5280088 | — | — | 1 | 8.18 |
| CHEMBL5287228 | — | — | 1 | 8.15 |
| CHEMBL5266178 | — | — | 1 | 8.13 |
| CHEMBL5276078 | — | — | 1 | 8.12 |
| CHEMBL5287748 | — | — | 1 | 8.10 |
| CHEMBL46909 | — | — | 1 | 8.09 |
| CHEMBL5269203 | — | — | 1 | 8.09 |
| CHEMBL5273468 | — | — | 1 | 8.06 |
| CHEMBL5278329 | — | — | 1 | 8.05 |
| CHEMBL5290366 | — | — | 1 | 8.04 |
| CHEMBL5282286 | — | — | 1 | 8.02 |
| CHEMBL5288164 | — | — | 1 | 7.96 |
| CHEMBL5268876 | — | — | 1 | 7.96 |
| CHEMBL5268442 | — | — | 1 | 7.94 |
| CHEMBL5280764 | — | — | 1 | 7.93 |
| CHEMBL5276233 | — | — | 1 | 7.90 |
| CHEMBL5278091 | — | — | 1 | 7.89 |
| CHEMBL5276009 | — | — | 1 | 7.89 |
| CHEMBL5268036 | — | — | 1 | 7.84 |
| CHEMBL5290026 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279681 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5287897 | — | IC50 | = | 0.551 | nM | 9.26 |
| CHEMBL5290149 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL5280516 | — | IC50 | = | 1.764 | nM | 8.75 |
| CHEMBL5289888 | — | IC50 | = | 3.915 | nM | 8.41 |
| CHEMBL5280415 | — | IC50 | = | 4.964 | nM | 8.30 |
| CHEMBL5283668 | — | IC50 | = | 6.062 | nM | 8.22 |
| CHEMBL5289447 | — | IC50 | = | 6.311 | nM | 8.20 |
| CHEMBL5272094 | — | IC50 | = | 6.494 | nM | 8.19 |
| CHEMBL5282966 | — | IC50 | = | 6.636 | nM | 8.18 |
| CHEMBL5280088 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5287228 | — | IC50 | = | 7.137 | nM | 8.15 |
| CHEMBL5266178 | — | IC50 | = | 7.452 | nM | 8.13 |
| CHEMBL5276078 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5287748 | — | IC50 | = | 7.875 | nM | 8.10 |
| CHEMBL46909 | — | IC50 | = | 8.225 | nM | 8.09 |
| CHEMBL5269203 | — | IC50 | = | 8.074 | nM | 8.09 |
| CHEMBL5273468 | — | IC50 | = | 8.672 | nM | 8.06 |
| CHEMBL5278329 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5290366 | — | IC50 | = | 9.093 | nM | 8.04 |
| CHEMBL5282286 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5288164 | — | IC50 | = | 11.06 | nM | 7.96 |
| CHEMBL5268876 | — | IC50 | = | 10.85 | nM | 7.96 |
| CHEMBL5268442 | — | IC50 | = | 11.58 | nM | 7.94 |
| CHEMBL5280764 | — | IC50 | = | 11.78 | nM | 7.93 |
| CHEMBL5276233 | — | IC50 | = | 12.72 | nM | 7.90 |
| CHEMBL5276009 | — | IC50 | = | 12.91 | nM | 7.89 |
| CHEMBL5278091 | — | IC50 | = | 12.91 | nM | 7.89 |
| CHEMBL5268036 | — | IC50 | = | 14.44 | nM | 7.84 |
| CHEMBL5290026 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5290901 | — | IC50 | = | 15.93 | nM | 7.80 |
| CHEMBL5270385 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5281938 | — | IC50 | = | 20.14 | nM | 7.70 |
| CHEMBL5280421 | — | IC50 | = | 22.19 | nM | 7.65 |
| CHEMBL5270417 | — | IC50 | = | 23.34 | nM | 7.63 |
| CHEMBL5268929 | — | IC50 | = | 26.82 | nM | 7.57 |
| CHEMBL5267009 | — | IC50 | = | 29.51 | nM | 7.53 |
| CHEMBL5275398 | — | IC50 | = | 33.14 | nM | 7.48 |
| CHEMBL5279084 | — | IC50 | = | 35.65 | nM | 7.45 |
| CHEMBL5270072 | — | IC50 | = | 39.02 | nM | 7.41 |
| CHEMBL5276124 | — | IC50 | = | 44.79 | nM | 7.35 |
| CHEMBL5280700 | — | IC50 | = | 51.28 | nM | 7.29 |
| CHEMBL5272757 | — | IC50 | = | 64.8 | nM | 7.19 |
| CHEMBL5285319 | — | IC50 | = | 65.1 | nM | 7.19 |
| CHEMBL5275310 | — | IC50 | = | 73.34 | nM | 7.13 |
| CHEMBL5268347 | — | IC50 | = | 76.81 | nM | 7.12 |
| CHEMBL5270659 | — | IC50 | = | 77.56 | nM | 7.11 |
| CHEMBL5278510 | — | IC50 | = | 86.24 | nM | 7.06 |
| CHEMBL5276355 | — | IC50 | = | 152.7 | nM | 6.82 |
| CHEMBL5278641 | — | IC50 | = | 156.16 | nM | 6.81 |