Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5240498

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human H3 receptor assessed as inhibition constant incubated for 90 mins by scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histamine H3 receptor (CHEMBL264)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H<sub>3</sub> and dopamine D<sub>3</sub> receptors.
Aranha CMSQ, Reiner-Link D, Leitzbach LR, Lopes FB, Stark H, Fernandes JPS.
Bioorg Med Chem (2023) 78 : 117132 -117132
PubMed 36542960 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.79 7.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4173854 1 7.79

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4173854 Ki = 16.1 nM 7.79