Assay Detail
Binding
CHEMBL5240952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of factor Xa (unknown origin) assessed as inhibition constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of pyrrolo[3,2-d]pyrimidineone derivatives as novel FXa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.68 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231779 | APIXABAN | 4.0 | 1 | 10.10 |
| CHEMBL1269025 | EDOXABAN | 4.0 | 1 | 9.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231779 | APIXABAN | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL1269025 | EDOXABAN | Ki | = | 0.561 | nM | 9.25 |