Assay Detail
Binding
CHEMBL5241479
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Irreversible inhibition of recombinant human BTK
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
If small molecules immunotherapy comes, can the prime be far behind?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.11 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973435 | — | — | 1 | 9.52 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.30 |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973435 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3707348 | ACALABRUTINIB | IC50 | = | 3.0 | nM | 8.52 |