Assay Detail
Binding
CHEMBL5241710
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Inhibition of BACE1 (unknown origin)
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 6.76 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197518 | — | — | 1 | 9.68 |
| CHEMBL5269238 | — | — | 1 | 9.32 |
| CHEMBL5286535 | — | — | 1 | 9.21 |
| CHEMBL5266033 | — | — | 1 | 9.20 |
| CHEMBL5272625 | — | — | 1 | 9.06 |
| CHEMBL5289994 | — | — | 1 | 8.77 |
| CHEMBL5267312 | — | — | 1 | 8.68 |
| CHEMBL5277927 | — | — | 1 | 8.53 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | 8.42 |
| CHEMBL5273978 | — | — | 1 | 8.35 |
| CHEMBL5291052 | — | — | 1 | 8.33 |
| CHEMBL5279409 | — | — | 1 | 8.23 |
| CHEMBL444478 | ACETOSIDE | 2.0 | 1 | 8.20 |
| CHEMBL5265752 | — | — | 1 | 7.86 |
| CHEMBL5272243 | — | — | 1 | 7.80 |
| CHEMBL5274465 | — | — | 1 | 7.78 |
| CHEMBL1613299 | — | — | 1 | 7.74 |
| CHEMBL5266286 | — | — | 1 | 7.73 |
| CHEMBL5268019 | — | — | 1 | 7.72 |
| CHEMBL5278429 | — | — | 1 | 7.65 |
| CHEMBL5275941 | — | — | 1 | 7.60 |
| CHEMBL5282833 | — | — | 1 | 7.49 |
| CHEMBL1950045 | HYDROXYTYROSOL | 3.0 | 1 | 7.46 |
| CHEMBL5272974 | — | — | 1 | 7.15 |
| CHEMBL5287982 | — | — | 1 | 6.61 |
| CHEMBL5268811 | — | — | 1 | 6.60 |
| CHEMBL5274016 | — | — | 1 | 6.56 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.28 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.26 |
| CHEMBL5287353 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197518 | — | IC50 | = | 0.211 | nM | 9.68 |
| CHEMBL5269238 | — | IC50 | = | 0.479 | nM | 9.32 |
| CHEMBL5286535 | — | IC50 | = | 0.624 | nM | 9.21 |
| CHEMBL5266033 | — | IC50 | = | 0.628 | nM | 9.20 |
| CHEMBL5272625 | — | IC50 | = | 0.864 | nM | 9.06 |
| CHEMBL5289994 | — | IC50 | = | 1.69 | nM | 8.77 |
| CHEMBL5267312 | — | IC50 | = | 2.07 | nM | 8.68 |
| CHEMBL5277927 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL226335 | RUTIN | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5273978 | — | IC50 | = | 4.45 | nM | 8.35 |
| CHEMBL5291052 | — | IC50 | = | 4.703 | nM | 8.33 |
| CHEMBL5279409 | — | IC50 | = | 5.87 | nM | 8.23 |
| CHEMBL444478 | ACETOSIDE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5265752 | — | IC50 | = | 13.82 | nM | 7.86 |
| CHEMBL5272243 | — | IC50 | = | 15.74 | nM | 7.80 |
| CHEMBL5274465 | — | IC50 | = | 16.69 | nM | 7.78 |
| CHEMBL1613299 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL5266286 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL5268019 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL5278429 | — | IC50 | = | 22.44 | nM | 7.65 |
| CHEMBL5275941 | — | IC50 | = | 25.07 | nM | 7.60 |
| CHEMBL5282833 | — | IC50 | = | 32.18 | nM | 7.49 |
| CHEMBL1950045 | HYDROXYTYROSOL | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5272974 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL5287982 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5268811 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL5274016 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL50 | QUERCETIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5287353 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5277231 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL443626 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5278221 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5274481 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL5272371 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL2235239 | Moslosooflavone | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL249448 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL517247 | MULBERROFURAN D | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL28 | APIGENIN | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL5280671 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL471187 | ECKOL | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL5278532 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL4097388 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL5270046 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL5273380 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 16670.0 | nM | 4.78 |
| CHEMBL5288752 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4089910 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5288184 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL5287890 | — | IC50 | = | 28900.0 | nM | 4.54 |