Assay Detail
Functional
CHEMBL5241967
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Antiproliferative activity against human LNCaP cells assessed as cell viability incubated for 96 hrs by Cell-Titer Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5288443 | — | — | 1 | 5.32 |
| CHEMBL2137199 | — | — | 1 | 5.27 |
| CHEMBL5275972 | — | — | 1 | 5.20 |
| CHEMBL5266226 | — | — | 1 | 5.09 |
| CHEMBL5279688 | — | — | 1 | 5.04 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5288443 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL2137199 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL5275972 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL5266226 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL5279688 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 42370.0 | nM | 4.37 |