Assay Detail
Binding
CHEMBL5242619
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Irreversible inhibition of BTK (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of small molecular inhibitors of the Bruton's tyrosine kinase (BTK) as a promising cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.96 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275119 | — | — | 1 | 9.30 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.30 |
| CHEMBL3301625 | SPEBRUTINIB | 2.0 | 1 | 9.15 |
| CHEMBL4650321 | ORELABRUTINIB | 3.0 | 1 | 8.80 |
| CHEMBL5285357 | — | — | 1 | 8.66 |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275119 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4650321 | ORELABRUTINIB | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5285357 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3707348 | ACALABRUTINIB | IC50 | = | 3.0 | nM | 8.52 |