Assay Detail
Binding
CHEMBL5243701
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Inhibition of human SOAT1 expressed in mouse AC29 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AC29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Sterol <i>O</i>-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.72 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46423 | NEVANIMIBE | 2.0 | 1 | 8.05 |
| CHEMBL5274065 | — | — | 1 | 5.54 |
| CHEMBL5284134 | — | — | 1 | 5.28 |
| CHEMBL5272794 | — | — | 1 | 4.92 |
| CHEMBL5267472 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46423 | NEVANIMIBE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5274065 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5284134 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5272794 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5267472 | — | IC50 | = | 15000.0 | nM | 4.82 |