Assay Detail
Binding
CHEMBL5244112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) by ADP Glo luminescent assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3Kδ inhibitors for hematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 9.00 |
| CHEMBL573339 | PI-103 | — | 1 | 8.15 |
| CHEMBL5277394 | — | — | 1 | 7.52 |
| CHEMBL5283525 | — | — | 1 | 7.51 |
| CHEMBL5273848 | — | — | 1 | 7.39 |
| CHEMBL5268761 | — | — | 1 | 7.34 |
| CHEMBL4217733 | — | — | 1 | 7.32 |
| CHEMBL5266749 | — | — | 1 | 7.31 |
| CHEMBL4209923 | — | — | 1 | 7.28 |
| CHEMBL5273428 | — | — | 1 | 7.17 |
| CHEMBL5274042 | — | — | 1 | 7.01 |
| CHEMBL5285343 | — | — | 1 | 6.98 |
| CHEMBL5286164 | — | — | 1 | 4.95 |
| CHEMBL5281587 | — | — | 1 | 4.49 |
| CHEMBL5282045 | — | — | 1 | 4.47 |
| CHEMBL5270285 | — | — | 1 | 4.33 |
| CHEMBL5272410 | — | — | 1 | 4.32 |
| CHEMBL5277136 | — | — | 1 | - |
| CHEMBL5289417 | — | — | 1 | - |
| CHEMBL5278908 | — | — | 1 | - |
| CHEMBL5290765 | — | — | 1 | - |
| CHEMBL5271533 | — | — | 1 | - |
| CHEMBL5279499 | — | — | 1 | - |
| CHEMBL5266503 | — | — | 1 | - |
| CHEMBL5289324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL573339 | PI-103 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5277394 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5283525 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5273848 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5268761 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4217733 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5266749 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4209923 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5273428 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5274042 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5285343 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5286164 | — | IC50 | = | 11325.0 | nM | 4.95 |
| CHEMBL5281587 | — | IC50 | = | 32538.0 | nM | 4.49 |
| CHEMBL5282045 | — | IC50 | = | 33525.0 | nM | 4.47 |
| CHEMBL5270285 | — | IC50 | = | 46616.0 | nM | 4.33 |
| CHEMBL5272410 | — | IC50 | = | 47529.0 | nM | 4.32 |
| CHEMBL5277136 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5289417 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5278908 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5290765 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5271533 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5279499 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5266503 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5289324 | — | IC50 | > | 50000.0 | nM | - |