Assay Detail
Functional
CHEMBL5244557
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Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human Erythrocyte measured after 72 hrs by SYBR green fluorescence dye based microplate reader analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial and antimalarial activities of quinolone derivatives: An overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.26 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5287020 | — | — | 1 | 10.70 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.30 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.22 |
| CHEMBL5267960 | — | — | 1 | 9.00 |
| CHEMBL2431813 | — | — | 1 | 9.00 |
| CHEMBL5279315 | — | — | 1 | 8.70 |
| CHEMBL527822 | — | — | 1 | 8.52 |
| CHEMBL5278844 | — | — | 1 | 7.92 |
| CHEMBL5272942 | — | — | 1 | 7.54 |
| CHEMBL5267580 | — | — | 1 | 7.35 |
| CHEMBL5283701 | — | — | 1 | 7.07 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.95 |
| CHEMBL5266501 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5287020 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5267960 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2431813 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5279315 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL527822 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5278844 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5272942 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5267580 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5283701 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5266501 | — | IC50 | = | 805.0 | nM | 6.09 |