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Assay Detail

CHEMBL5244609

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FBPase (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fructose-1,6-bisphosphatase 1 (CHEMBL3975)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Current anti-diabetic agents and their molecular targets: A review.
Kerru N, Singh-Pillay A, Awolade P, Singh P.
Eur J Med Chem (2018) 152 : 436 -488
PubMed 29751237 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.50 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3287959 1 5.88
CHEMBL3287977 1 5.53
CHEMBL1521269 1 5.35
CHEMBL3287957 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3287959 IC50 = 1320.0 nM 5.88
CHEMBL3287977 IC50 = 2980.0 nM 5.53
CHEMBL1521269 IC50 = 4510.0 nM 5.35
CHEMBL3287957 IC50 = 5610.0 nM 5.25