Assay Detail
Binding
CHEMBL5245697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FTO (unknown origin) mediated m6A methylation by HPLC analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent developments of small molecules targeting RNA m<sup>6</sup>A modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.40 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572939 | — | — | 1 | 7.22 |
| CHEMBL4567838 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572939 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4567838 | — | IC50 | = | 2600.0 | nM | 5.58 |