Assay Detail
Binding
CHEMBL5246367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.42 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138065 | — | — | 1 | 8.63 |
| CHEMBL5286592 | — | — | 1 | 7.35 |
| CHEMBL5279574 | — | — | 1 | 7.31 |
| CHEMBL1673027 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138065 | — | IC50 | = | 2.36 | nM | 8.63 |
| CHEMBL5286592 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5279574 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1673027 | — | IC50 | = | 396.0 | nM | 6.40 |