Assay Detail
Binding
CHEMBL5246402
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Inhibition of PTP1B (unknown origin) assessed as inhibition constant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.56 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184444 | — | — | 1 | 9.04 |
| CHEMBL5279725 | — | — | 1 | 8.62 |
| CHEMBL140120 | — | — | 1 | 6.57 |
| CHEMBL138257 | — | — | 1 | 5.60 |
| CHEMBL342478 | — | — | 1 | 5.10 |
| CHEMBL336879 | — | — | 1 | 4.43 |
| CHEMBL186337 | — | — | 1 | - |
| CHEMBL117869 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184444 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL5279725 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL140120 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL138257 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL342478 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL336879 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL186337 | — | Ki | = | 2.1 | nM | - |
| CHEMBL117869 | — | Ki | = | 6.9 | nM | - |