Assay Detail
Binding
CHEMBL5246773
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Binding affinity to recombinant human ETA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL957 | BOSENTAN | 4.0 | 1 | 7.10 |
| CHEMBL4438132 | — | — | 1 | 6.10 |
| CHEMBL4525321 | — | — | 1 | 5.82 |
| CHEMBL5272983 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL957 | BOSENTAN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4438132 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4525321 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5272983 | — | IC50 | = | 18000.0 | nM | 4.75 |