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Assay Detail

CHEMBL5246790

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Functional
Antimalarial activity against Plasmodium falciparum NF54
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.
Patel OPS, Beteck RM, Legoabe LJ.
Eur J Med Chem (2021) 213 : 113193 -113193
PubMed 33508479 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 8.46 9.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5290797 1 9.31
CHEMBL5289927 1 8.97
CHEMBL5266690 1 8.92
CHEMBL5285811 1 8.89
CHEMBL5275788 1 8.74
CHEMBL566534 ARTEMETHER 4.0 2 8.70
CHEMBL5286129 1 8.69
CHEMBL5281206 1 8.59
CHEMBL5283170 1 8.51
CHEMBL5177723 1 8.49
CHEMBL5276997 1 8.37
CHEMBL5268191 1 8.35
CHEMBL5267450 1 8.34
CHEMBL5270134 1 8.32
CHEMBL3601443 1 8.29
CHEMBL5290713 1 8.25
CHEMBL5288216 1 7.51
CHEMBL5288233 1 7.11
CHEMBL5287408 1 -
CHEMBL227855 1 -
CHEMBL404431 OZ277 3.0 1 -
CHEMBL361497 ARTESUNATE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5290797 IC50 = 0.49 nM 9.31
CHEMBL5289927 IC50 = 1.06 nM 8.97
CHEMBL5266690 IC50 = 1.21 nM 8.92
CHEMBL5285811 IC50 = 1.3 nM 8.89
CHEMBL5275788 IC50 = 1.83 nM 8.74
CHEMBL566534 ARTEMETHER IC50 = 2.0 nM 8.70
CHEMBL5286129 IC50 = 2.04 nM 8.69
CHEMBL5281206 IC50 = 2.6 nM 8.59
CHEMBL5283170 IC50 = 3.1 nM 8.51
CHEMBL5177723 IC50 = 3.2 nM 8.49
CHEMBL5276997 IC50 = 4.3 nM 8.37
CHEMBL5268191 IC50 = 4.5 nM 8.35
CHEMBL5267450 IC50 = 4.6 nM 8.34
CHEMBL5270134 IC50 = 4.8 nM 8.32
CHEMBL3601443 IC50 = 5.1 nM 8.29
CHEMBL5290713 IC50 = 5.68 nM 8.25
CHEMBL5288216 IC50 = 31.0 nM 7.51
CHEMBL5288233 IC50 = 78.0 nM 7.11
CHEMBL227855 IC50 = 0.00042 ug.mL-1 -
CHEMBL404431 OZ277 IC50 = 0.00091 ug.mL-1 -
CHEMBL361497 ARTESUNATE IC50 = 0.0012 ug.mL-1 -
CHEMBL5287408 IC50 = 0.00036 ug.mL-1 -
CHEMBL566534 ARTEMETHER IC50 = 0.0012 ug.mL-1 -