Assay Detail
Functional
CHEMBL5246793
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.27 | 8.89 |
| EC50 | 2 | 8.95 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275541 | — | — | 1 | 9.28 |
| CHEMBL4643812 | — | — | 1 | 8.89 |
| CHEMBL3037955 | — | — | 1 | 8.85 |
| CHEMBL4633803 | — | — | 1 | 8.72 |
| CHEMBL4638197 | — | — | 1 | 8.72 |
| CHEMBL5278334 | — | — | 1 | 8.62 |
| CHEMBL85223 | — | — | 1 | 8.19 |
| CHEMBL5280675 | — | — | 1 | 8.09 |
| CHEMBL5271660 | — | — | 1 | 8.07 |
| CHEMBL85891 | — | — | 1 | 8.03 |
| CHEMBL5290592 | — | — | 1 | 7.98 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.73 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275541 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4643812 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3037955 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4633803 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4638197 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5278334 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL85223 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5280675 | — | IC50 | = | 8.08 | nM | 8.09 |
| CHEMBL5271660 | — | IC50 | = | 8.54 | nM | 8.07 |
| CHEMBL85891 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5290592 | — | IC50 | = | 10.58 | nM | 7.98 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 18.43 | nM | 7.73 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 18.43 | nM | 7.73 |