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Compound Detail

CHEMBL85891

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CC1(OCc2ccccc2)CCC2CC1OO[C@]2(C)CS(=O)(=O)c1ccccc1

Basic Information

ChEMBL ID CHEMBL85891
Phase Preclinical
Structure Type MOL
InChI Key RQVQHBMHARIASC-SXTOGUAFSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

416.5
MW (Da)
4.33
ALogP
5
HBA
0
HBD
61.8
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H28O5S
MW 416.54
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness 0.73

Activity Summary

IC50 5 meas. best 8.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
IC50 8.03 8.03 9.4 4
Unchecked
CHEMBL612545
IC50 8.03 8.03 9.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12773055 10.1021/jm020584a Mus musculus 7
12773055 10.1021/jm020584a Unchecked 1
15163175 10.1021/jm030571c Plasmodium falciparum 1
15163175 10.1021/jm030571c Mus musculus 1
16527481 10.1016/j.bmcl.2006.02.059 Plasmodium falciparum 1
- 10.1039/C2MD00277A Plasmodium falciparum 1
33508479 10.1016/j.ejmech.2021.113193 Plasmodium falciparum 1

Data from ChEMBL 36 via Core Engine