Assay Detail
Functional
CHEMBL747313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antimalarial activity against chloroquine-sensitive NF54 strain of Plasmodium falciparum
48
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.10 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85223 | — | — | 1 | 8.19 |
| CHEMBL85891 | — | — | 1 | 8.03 |
| CHEMBL82918 | — | — | 1 | 7.85 |
| CHEMBL541715 | — | — | 2 | 7.85 |
| CHEMBL85002 | — | — | 3 | 7.77 |
| CHEMBL85279 | — | — | 1 | 7.77 |
| CHEMBL82507 | — | — | 3 | 7.77 |
| CHEMBL315514 | — | — | 1 | 7.68 |
| CHEMBL83346 | — | — | 1 | 7.62 |
| CHEMBL84769 | — | — | 1 | 7.50 |
| CHEMBL315549 | — | — | 1 | 7.46 |
| CHEMBL82724 | — | — | 1 | 7.43 |
| CHEMBL86069 | — | — | 1 | 7.34 |
| CHEMBL84261 | — | — | 1 | 7.31 |
| CHEMBL82631 | — | — | 1 | 7.28 |
| CHEMBL83407 | — | — | 2 | 7.27 |
| CHEMBL84824 | — | — | 2 | 7.26 |
| CHEMBL380230 | ARTEFLENE | 2.0 | 1 | 7.15 |
| CHEMBL315213 | — | — | 1 | 7.14 |
| CHEMBL431991 | — | — | 1 | 7.14 |
| CHEMBL83812 | — | — | 1 | 7.09 |
| CHEMBL82620 | — | — | 2 | 7.05 |
| CHEMBL315350 | — | — | 1 | 7.04 |
| CHEMBL309252 | — | — | 1 | 6.85 |
| CHEMBL85259 | — | — | 1 | 6.82 |
| CHEMBL84991 | — | — | 1 | 6.82 |
| CHEMBL88052 | — | — | 1 | 6.77 |
| CHEMBL85034 | — | — | 1 | 6.77 |
| CHEMBL315091 | — | — | 1 | 6.44 |
| CHEMBL84823 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85223 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL85891 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL541715 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL82918 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL85002 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL85279 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL82507 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL82507 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL85002 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL315514 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL83346 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL84769 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL315549 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL82724 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL541715 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL86069 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL84261 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL82631 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL83407 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL84824 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL83407 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL380230 | ARTEFLENE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL431991 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL315213 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL83812 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL82620 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL315350 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL84824 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL82620 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL309252 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL84991 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL85259 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL88052 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL85034 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL82507 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL85002 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL315091 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL84823 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL313706 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL311233 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL421338 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL315698 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL418932 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL309208 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL419106 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL82849 | — | IC50 | < | 3220.0 | nM | - |
| CHEMBL84992 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL84218 | — | IC50 | > | 2500.0 | nM | - |