Assay Detail
Binding
CHEMBL5247064
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Inhibition of ACAT in human THP-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.15 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33780 | — | — | 1 | 7.40 |
| CHEMBL5284960 | — | — | 1 | 7.22 |
| CHEMBL5275490 | — | — | 1 | 7.16 |
| CHEMBL5267175 | — | — | 1 | 6.80 |
| CHEMBL5284543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33780 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5284960 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5275490 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5267175 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5284543 | — | IC50 | > | 500.0 | nM | - |