Assay Detail
Functional
CHEMBL5247155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus genotype 1a harboring NS5A Y93H mutant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.30 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3971095 | RUZASVIR | 2.0 | 1 | 10.22 |
| CHEMBL3039514 | ELBASVIR | 4.0 | 1 | 8.62 |
| CHEMBL3828072 | — | — | 1 | 8.30 |
| CHEMBL3765311 | — | — | 1 | 7.57 |
| CHEMBL5272001 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3971095 | RUZASVIR | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL3039514 | ELBASVIR | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3828072 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3765311 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5272001 | — | EC50 | = | 170.0 | nM | 6.77 |