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Compound Detail

CHEMBL5272001

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COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)CCn2c-3cc3cc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)ccc32)[nH]1)C(C)C

Basic Information

ChEMBL ID CHEMBL5272001
Phase Preclinical
Structure Type MOL
InChI Key ULMMERLNYALKDW-OVBQHIIOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

804.0
MW (Da)
6.73
ALogP
9
HBA
4
HBD
179.6
PSA (Ų)
0.12
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H53N9O6
MW 803.96
Aromatic Rings 5
Heavy Atoms 59
NP-Likeness -0.36

Activity Summary

EC50 1 meas. best 6.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 6.77 6.77 170.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hepatitis C virus EC50 = 170.0 nM 6.77 Antiviral activity against Hepatitis C virus genotype 1a harboring NS5A Y93H mut... 34213340

Literature References

PubMed DOI Target Context # Activities
34213340 10.1021/acs.jmedchem.1c00790 Hepatitis C virus 1

Data from ChEMBL 36 via Core Engine