Assay Detail
Binding
CHEMBL5247267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat TRPV1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL5102) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.40 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229430 | AMG-517 | 1.0 | 1 | 9.05 |
| CHEMBL226574 | — | — | 1 | 8.43 |
| CHEMBL229431 | — | — | 1 | 7.57 |
| CHEMBL229432 | — | — | 1 | 6.48 |
| CHEMBL375460 | — | — | 1 | 6.46 |
| CHEMBL227209 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229430 | AMG-517 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL226574 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL229431 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL229432 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL375460 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL227209 | — | IC50 | = | 380.0 | nM | 6.42 |