Assay Detail
Binding
CHEMBL5247319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS CoV-2 Main protease incubated for 10 min by FRET assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.36 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5267069 | — | — | 1 | 8.12 |
| CHEMBL5275426 | — | — | 1 | 8.12 |
| CHEMBL5275166 | — | — | 1 | 8.04 |
| CHEMBL5287318 | — | — | 1 | 7.91 |
| CHEMBL5288416 | — | — | 1 | 7.89 |
| CHEMBL5282244 | — | — | 1 | 7.88 |
| CHEMBL5269547 | — | — | 1 | 7.88 |
| CHEMBL5269544 | — | — | 1 | 7.84 |
| CHEMBL5195325 | — | — | 1 | 7.82 |
| CHEMBL5275295 | — | — | 1 | 7.78 |
| CHEMBL5277900 | — | — | 1 | 7.76 |
| CHEMBL5270743 | — | — | 1 | 7.76 |
| CHEMBL5270522 | — | — | 1 | 7.73 |
| CHEMBL5276490 | — | — | 1 | 7.72 |
| CHEMBL5288153 | — | — | 1 | 7.71 |
| CHEMBL5267952 | — | — | 1 | 7.52 |
| CHEMBL5290856 | — | — | 1 | 7.46 |
| CHEMBL5278216 | — | — | 1 | 7.44 |
| CHEMBL5286331 | — | — | 1 | 7.43 |
| CHEMBL4764751 | — | — | 1 | 7.40 |
| CHEMBL5286326 | — | — | 1 | 7.36 |
| CHEMBL5287690 | — | — | 1 | 7.29 |
| CHEMBL5287688 | — | — | 1 | 7.28 |
| CHEMBL4796938 | — | — | 1 | 7.28 |
| CHEMBL5274687 | — | — | 1 | 7.16 |
| CHEMBL5282049 | — | — | 1 | 7.03 |
| CHEMBL5278207 | — | — | 1 | 6.82 |
| CHEMBL5281031 | — | — | 1 | 6.71 |
| CHEMBL5290455 | — | — | 1 | 6.53 |
| CHEMBL5284630 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5267069 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5275426 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5275166 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5287318 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL5288416 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5282244 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL5269547 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5269544 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL5195325 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5275295 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL5277900 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5270743 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL5270522 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL5276490 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5288153 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL5267952 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5290856 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL5278216 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL5286331 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4764751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5286326 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL5287690 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL5287688 | — | IC50 | = | 52.1 | nM | 7.28 |
| CHEMBL4796938 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5274687 | — | IC50 | = | 69.1 | nM | 7.16 |
| CHEMBL5282049 | — | IC50 | = | 93.5 | nM | 7.03 |
| CHEMBL5278207 | — | IC50 | = | 153.1 | nM | 6.82 |
| CHEMBL5281031 | — | IC50 | = | 195.6 | nM | 6.71 |
| CHEMBL5290455 | — | IC50 | = | 298.8 | nM | 6.53 |
| CHEMBL5284630 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL5274857 | — | IC50 | = | 378.2 | nM | 6.42 |
| CHEMBL5284199 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL5286696 | — | IC50 | = | 525.9 | nM | 6.28 |
| CHEMBL5273500 | — | IC50 | = | 748.5 | nM | 6.13 |