Assay Detail
Binding
CHEMBL5247339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS CoV-2 Main protease using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 peptide as substrate by fluorescence based analysis
31
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.51 | 7.13 |
| Ki | 2 | 7.31 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266355 | — | — | 2 | 7.51 |
| CHEMBL5179454 | — | — | 2 | 7.11 |
| CHEMBL468553 | — | — | 1 | 7.09 |
| CHEMBL3655715 | — | — | 1 | 6.89 |
| CHEMBL4079667 | — | — | 1 | 6.89 |
| CHEMBL5283181 | — | — | 1 | 6.82 |
| CHEMBL5267356 | — | — | 1 | 6.82 |
| CHEMBL99313 | — | — | 1 | 6.77 |
| CHEMBL1435753 | — | — | 1 | 6.64 |
| CHEMBL4779667 | — | — | 1 | 6.62 |
| CHEMBL5195364 | — | — | 1 | 6.58 |
| CHEMBL5270064 | — | — | 1 | 6.48 |
| CHEMBL1336959 | — | — | 1 | 6.48 |
| CHEMBL4552531 | — | — | 1 | 6.46 |
| CHEMBL4060715 | — | — | 1 | 6.44 |
| CHEMBL1394251 | — | — | 1 | 6.42 |
| CHEMBL98386 | — | — | 1 | 6.41 |
| CHEMBL4068618 | — | — | 1 | 6.39 |
| CHEMBL5277713 | — | — | 1 | 6.39 |
| CHEMBL45016 | — | — | 1 | 6.39 |
| CHEMBL3219171 | — | — | 1 | 6.32 |
| CHEMBL45152 | — | — | 1 | 6.31 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.28 |
| CHEMBL2391913 | — | — | 1 | 6.20 |
| CHEMBL4783878 | — | — | 1 | 6.19 |
| CHEMBL297304 | — | — | 1 | 6.18 |
| CHEMBL5280783 | — | — | 1 | 6.14 |
| CHEMBL1710047 | — | — | 1 | 6.11 |
| CHEMBL5274064 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266355 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL5266355 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5179454 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL468553 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5179454 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4079667 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3655715 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5267356 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5283181 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL99313 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1435753 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4779667 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5195364 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1336959 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5270064 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4552531 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4060715 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1394251 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL98386 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4068618 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL45016 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5277713 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3219171 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL45152 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL51085 | EBSELEN | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2391913 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4783878 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL297304 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5280783 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1710047 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5274064 | — | IC50 | = | 910.0 | nM | 6.04 |