Assay Detail

CHEMBL5248952

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Functional

Antitumor activity against human HL60 cells assessed as cell growth incubated for 1 day by MTT assay

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

Open DB target context

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Natural occurrence, bioactivity, and biosynthesis of triene-ansamycins.

Yang X, Wu W, Li H, Zhang M, Chu Z, Wang X, Sun P.
Eur J Med Chem (2022) 244 : 114815 -114815
PubMed 36240545 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.11	8.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5274453	—	—	1	8.11
CHEMBL5270349	—	—	1	8.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5274453	—	IC50	=	7.7	nM	8.11
CHEMBL5270349	—	IC50	=	7.7	nM	8.11