Assay Detail
Binding
CHEMBL5249967
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Inhibition of PRMT5 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal chemistry strategies targeting PRMT5 for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.45 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249337 | ONAMETOSTAT | 1.0 | 1 | 9.11 |
| CHEMBL4585781 | — | — | 1 | 8.37 |
| CHEMBL5281295 | — | — | 1 | 8.28 |
| CHEMBL4168754 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249337 | ONAMETOSTAT | IC50 | = | 0.772 | nM | 9.11 |
| CHEMBL4585781 | — | IC50 | = | 4.27 | nM | 8.37 |
| CHEMBL5281295 | — | IC50 | = | 5.23 | nM | 8.28 |
| CHEMBL4168754 | — | IC50 | = | 9.51 | nM | 8.02 |