Assay Detail
Binding
CHEMBL5250359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ULK1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.84 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280560 | — | — | 1 | 8.80 |
| CHEMBL5266681 | — | — | 1 | 8.54 |
| CHEMBL3605055 | — | — | 1 | 8.10 |
| CHEMBL5269042 | — | — | 1 | 8.08 |
| CHEMBL5279228 | — | — | 1 | 7.51 |
| CHEMBL5276694 | — | — | 1 | 7.51 |
| CHEMBL5288376 | — | — | 1 | 7.35 |
| CHEMBL5274568 | — | — | 1 | 6.80 |
| CHEMBL5270018 | — | — | 1 | - |
| CHEMBL5278632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280560 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5266681 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3605055 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5269042 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5279228 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5276694 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5288376 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5274568 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5270018 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL5278632 | — | IC50 | > | 300.0 | nM | - |