Compound Detail
CHEMBL5266681
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5266681 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UEZRAYLQPKCVRW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
450.6
MW (Da)
3.26
ALogP
7
HBA
3
HBD
91.4
PSA (Ų)
0.45
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase ULK2 CHEMBL5435 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Serine/threonine-protein kinase ULK1 CHEMBL6006 | IC50 | 8.54 | 8.54 | 2.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase ULK2 | IC50 | = | 1.1 | nM | 8.96 | Inhibition of ULK2 (unknown origin) | 36283182 |
| Serine/threonine-protein kinase ULK1 | IC50 | = | 2.9 | nM | 8.54 | Inhibition of ULK1 (unknown origin) | 36283182 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36283182 | 10.1016/j.ejmech.2022.114846 | Serine/threonine-protein kinase ULK1 | 1 |
| 36283182 | 10.1016/j.ejmech.2022.114846 | Serine/threonine-protein kinase ULK2 | 1 |
| 36283182 | 10.1016/j.ejmech.2022.114846 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine