Assay Detail
Binding
CHEMBL5250361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VPS34 (unknown origin)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.04 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273832 | — | — | 1 | 9.30 |
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.38 |
| CHEMBL13513 | — | — | 1 | 7.77 |
| CHEMBL4639853 | — | — | 1 | 7.72 |
| CHEMBL5277117 | — | — | 1 | 7.70 |
| CHEMBL5275440 | — | — | 1 | 7.64 |
| CHEMBL3913746 | — | — | 1 | 7.60 |
| CHEMBL5274326 | — | — | 1 | 7.44 |
| CHEMBL5281192 | — | — | 1 | 7.31 |
| CHEMBL5287349 | — | — | 1 | 7.28 |
| CHEMBL268976 | — | — | 1 | 7.27 |
| CHEMBL5281260 | — | — | 1 | 7.23 |
| CHEMBL5282812 | — | — | 1 | 7.21 |
| CHEMBL5270095 | — | — | 1 | 7.11 |
| CHEMBL5285942 | — | — | 1 | 7.11 |
| CHEMBL276865 | — | — | 1 | 7.10 |
| CHEMBL5267007 | — | — | 1 | 6.96 |
| CHEMBL5269785 | — | — | 1 | 6.92 |
| CHEMBL3604928 | — | — | 1 | 6.84 |
| CHEMBL5275891 | — | — | 1 | 6.82 |
| CHEMBL5273375 | — | — | 1 | 6.67 |
| CHEMBL276894 | — | — | 1 | 6.57 |
| CHEMBL5272049 | — | — | 1 | 6.54 |
| CHEMBL5278884 | — | — | 1 | 6.51 |
| CHEMBL5279542 | — | — | 1 | 6.51 |
| CHEMBL5290510 | — | — | 1 | 6.38 |
| CHEMBL5267751 | — | — | 1 | 6.20 |
| CHEMBL13512 | — | — | 1 | 5.34 |
| CHEMBL292268 | 3-METHYLADENINE | — | 1 | 4.60 |
| CHEMBL416892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273832 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL428496 | WORTMANNIN | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL13513 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4639853 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5277117 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5275440 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3913746 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5274326 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5281192 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5287349 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL268976 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5281260 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5282812 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5270095 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5285942 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL276865 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5267007 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5269785 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL3604928 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5275891 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5273375 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL276894 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL5272049 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL5278884 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5279542 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5290510 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL5267751 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL13512 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL292268 | 3-METHYLADENINE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL416892 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL275536 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL5286850 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL5281391 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL5266610 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL5284991 | — | IC50 | >= | 500.0 | nM | - |