Assay Detail
Functional
CHEMBL5250525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells incubated for 74 to 76 hrs by cell counting kit 8 method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.49 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4582651 | PRALSETINIB | 4.0 | 1 | 5.93 |
| CHEMBL5284144 | — | — | 1 | 5.87 |
| CHEMBL5278045 | — | — | 1 | 5.77 |
| CHEMBL5278993 | — | — | 1 | 5.51 |
| CHEMBL5279334 | — | — | 1 | 5.49 |
| CHEMBL5286410 | — | — | 1 | 5.36 |
| CHEMBL5290506 | — | — | 1 | 5.35 |
| CHEMBL5275850 | — | — | 1 | 5.32 |
| CHEMBL5284865 | — | — | 1 | 5.25 |
| CHEMBL5270601 | — | — | 1 | 5.01 |
| CHEMBL5275312 | — | — | 1 | - |
| CHEMBL5274689 | — | — | 1 | - |
| CHEMBL5284208 | — | — | 1 | - |
| CHEMBL5280596 | — | — | 1 | - |
| CHEMBL5272928 | — | — | 1 | - |
| CHEMBL5282607 | — | — | 1 | - |
| CHEMBL5288736 | — | — | 1 | - |
| CHEMBL5287431 | — | — | 1 | - |
| CHEMBL5284668 | — | — | 1 | - |
| CHEMBL5291008 | — | — | 1 | - |
| CHEMBL5285965 | — | — | 1 | - |
| CHEMBL5269214 | — | — | 1 | - |
| CHEMBL5279026 | — | — | 1 | - |
| CHEMBL5287259 | — | — | 1 | - |
| CHEMBL5273620 | — | — | 1 | - |
| CHEMBL5289571 | — | — | 1 | - |
| CHEMBL5268831 | — | — | 1 | - |
| CHEMBL4559134 | SELPERCATINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4582651 | PRALSETINIB | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5284144 | — | IC50 | = | 1355.0 | nM | 5.87 |
| CHEMBL5278045 | — | IC50 | = | 1708.0 | nM | 5.77 |
| CHEMBL5278993 | — | IC50 | = | 3062.0 | nM | 5.51 |
| CHEMBL5279334 | — | IC50 | = | 3212.0 | nM | 5.49 |
| CHEMBL5286410 | — | IC50 | = | 4328.0 | nM | 5.36 |
| CHEMBL5290506 | — | IC50 | = | 4477.0 | nM | 5.35 |
| CHEMBL5275850 | — | IC50 | = | 4796.0 | nM | 5.32 |
| CHEMBL5284865 | — | IC50 | = | 5654.0 | nM | 5.25 |
| CHEMBL5270601 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL5275312 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5274689 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5284208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5280596 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5272928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5282607 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5288736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5287431 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5284668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5291008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5285965 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5269214 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5279026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5287259 | — | IC50 | - | — | - | |
| CHEMBL5273620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5289571 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5268831 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4559134 | SELPERCATINIB | IC50 | > | 10000.0 | nM | - |