Assay Detail
Functional
CHEMBL5250635
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Antiviral activity against HCMV Davis infected in HELF cells assessed as reduction in viral replication
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HELF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.19 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.60 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.78 |
| CHEMBL5286815 | — | — | 1 | - |
| CHEMBL5291013 | — | — | 1 | - |
| CHEMBL5287352 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5286815 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5291013 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5287352 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | - | — | - | |
| CHEMBL31634 | BRIVUDINE | EC50 | - | — | - |