Assay Detail
Functional
CHEMBL5250657
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Induction of ferroptosis in human HT-1080 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747331 | — | — | 1 | 7.00 |
| CHEMBL401989 | ERASTIN | — | 1 | 6.70 |
| CHEMBL5271368 | — | — | 1 | 4.12 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747331 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL401989 | ERASTIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5271368 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 450000.0 | nM | - |