Assay Detail
Functional
CHEMBL5252147
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Antiparasitic activity against Cryptosporidium parvum infected in human HCT-8 cells assessed as parasitic growth inhibition measured for 48 hrs by fluorescence based microscopic analysis
56
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptosporidium parvum |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 28 | - | - |
| EC50 | 28 | 6.70 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297269 | OSUGACESTAT | 2.0 | 2 | 8.74 |
| CHEMBL5277661 | — | — | 2 | 8.19 |
| CHEMBL5290152 | — | — | 2 | 7.75 |
| CHEMBL5269363 | — | — | 2 | 7.60 |
| CHEMBL5268899 | — | — | 2 | 7.51 |
| CHEMBL5280057 | — | — | 2 | 7.28 |
| CHEMBL5289461 | — | — | 2 | 7.11 |
| CHEMBL5283121 | — | — | 2 | 7.09 |
| CHEMBL5288459 | — | — | 2 | 6.96 |
| CHEMBL5277099 | — | — | 2 | 6.96 |
| CHEMBL5275988 | — | — | 2 | 6.96 |
| CHEMBL5283775 | — | — | 2 | 6.55 |
| CHEMBL5268967 | — | — | 2 | 6.50 |
| CHEMBL5269620 | — | — | 2 | 6.46 |
| CHEMBL5290986 | — | — | 2 | 6.26 |
| CHEMBL5289149 | — | — | 2 | 5.84 |
| CHEMBL5288433 | — | — | 2 | 5.77 |
| CHEMBL5268841 | — | — | 2 | 5.64 |
| CHEMBL5283923 | — | — | 2 | 5.60 |
| CHEMBL5266604 | — | — | 2 | 5.26 |
| CHEMBL5286214 | — | — | 2 | 4.60 |
| CHEMBL5271513 | — | — | 2 | - |
| CHEMBL5274430 | — | — | 2 | - |
| CHEMBL5282809 | — | — | 2 | - |
| CHEMBL5280809 | — | — | 2 | - |
| CHEMBL5287140 | — | — | 2 | - |
| CHEMBL5272298 | — | — | 2 | - |
| CHEMBL5281234 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297269 | OSUGACESTAT | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5277661 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5290152 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5269363 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5268899 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5280057 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5289461 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5283121 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5288459 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5277099 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5275988 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5283775 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5268967 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5269620 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5290986 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5289149 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5288433 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5268841 | — | EC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5283923 | — | EC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL5266604 | — | EC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL5286214 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5275988 | — | EC90 | = | 0.21 | uM | - |
| CHEMBL5283923 | — | EC90 | = | 11.1 | uM | - |
| CHEMBL5289461 | — | EC90 | = | 0.16 | uM | - |
| CHEMBL5268899 | — | EC90 | = | 0.066 | uM | - |
| CHEMBL5283121 | — | EC90 | = | 0.15 | uM | - |
| CHEMBL5281234 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5280057 | — | EC90 | = | 0.1 | uM | - |
| CHEMBL5277661 | — | EC90 | = | 0.016 | uM | - |
| CHEMBL5288459 | — | EC90 | = | 0.23 | uM | - |
| CHEMBL5286214 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5287140 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5280809 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5282809 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5271513 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5268841 | — | EC90 | = | 4.9 | uM | - |
| CHEMBL5272298 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5266604 | — | EC90 | = | 12.8 | uM | - |
| CHEMBL5268967 | — | EC90 | = | 0.96 | uM | - |
| CHEMBL5288433 | — | EC90 | = | 3.61 | uM | - |
| CHEMBL5269363 | — | EC90 | = | 0.055 | uM | - |
| CHEMBL5281234 | — | EC90 | > | 25.0 | uM | - |
| CHEMBL5274430 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5271513 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5282809 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5277099 | — | EC90 | = | 0.31 | uM | - |
| CHEMBL5272298 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5287140 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4297269 | OSUGACESTAT | EC90 | = | 0.0023 | uM | - |
| CHEMBL5280809 | — | EC50 | > | 25000.0 | nM | - |