Assay Detail
Functional
CHEMBL5252785
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Antiproliferative activity against mouse BaF3 cells expressing Tel-KDR-myc1.3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5288744 | — | — | 1 | 8.70 |
| CHEMBL4080062 | BFH-772 | 2.0 | 1 | 8.70 |
| CHEMBL4104297 | — | — | 1 | 8.40 |
| CHEMBL5280119 | — | — | 1 | 8.30 |
| CHEMBL5276611 | — | — | 1 | 8.05 |
| CHEMBL153843 | — | — | 1 | 7.89 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.85 |
| CHEMBL75232 | — | — | 1 | 6.67 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5288744 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4080062 | BFH-772 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4104297 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5280119 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5276611 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL153843 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL75232 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL535 | SUNITINIB | IC50 | = | 238.0 | nM | 6.62 |