Assay Detail
Functional
CHEMBL5252789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.21 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.92 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.46 |
| CHEMBL5280119 | — | — | 1 | 5.32 |
| CHEMBL5288744 | — | — | 1 | 5.25 |
| CHEMBL5276611 | — | — | 1 | 5.09 |
| CHEMBL4104297 | — | — | 1 | - |
| CHEMBL4080062 | BFH-772 | 2.0 | 1 | - |
| CHEMBL75232 | — | — | 1 | - |
| CHEMBL153843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL535 | SUNITINIB | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5280119 | — | IC50 | = | 4778.0 | nM | 5.32 |
| CHEMBL5288744 | — | IC50 | = | 5646.0 | nM | 5.25 |
| CHEMBL5276611 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4104297 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080062 | BFH-772 | IC50 | > | 10000.0 | nM | - |
| CHEMBL75232 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153843 | — | IC50 | > | 5500.0 | nM | - |