Assay Detail

CHEMBL5252986

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Functional

Antiviral activity against HIV1 LAV assessed as inhibition of virus-induced cytopathic effect

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Ghosh AK, Osswald HL, Prato G.
J Med Chem (2016) 59 : 5172 -5208
PubMed 26799988 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.74	8.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1232930	—	—	1	8.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1232930	—	IC50	=	1.8	nM	8.74