Assay Detail
Functional
CHEMBL5253233
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Cytotoxicity against doxorubicin-resistant human NCI/ADR-RES cells assessed as inhibition of cell growth incubated for 90 mins by crystal violet staining assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.57 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217089 | DOXAZOLIDINE | — | 2 | 7.32 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 2 | 6.21 |
| CHEMBL417 | EPIRUBICIN | 4.0 | 2 | 6.20 |
| CHEMBL1255 | FORMALDEHYDE | -1.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217089 | DOXAZOLIDINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL217089 | DOXAZOLIDINE | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1255 | FORMALDEHYDE | IC50 | = | 501187.23 | nM | - |
| CHEMBL1255 | FORMALDEHYDE | IC50 | = | 530000.0 | nM | - |