Compound Detail
CHEMBL1255
FORMALDEHYDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1255 |
| Name | FORMALDEHYDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WSFSSNUMVMOOMR-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
6
Activities
1
Assay Types
1
PK Parameters
17
Publications
13
Known Names
Molecular Properties
30.0
MW (Da)
-0.18
ALogP
1
HBA
0
HBD
17.1
PSA (Ų)
0.36
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 6 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MIA PaCa-2 CHEMBL614725 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.025 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MIA PaCa-2 | IC50 | = | 500.0 | nM | 6.3 | Synergistic cytotoxicity against doxorubicin-sensitive human MIA PaCa-2 cells as... | 26881291 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26881291 | 10.1021/acs.jmedchem.5b01956 | NCI/ADR-RES | 10 |
| 26881291 | 10.1021/acs.jmedchem.5b01956 | MIA PaCa-2 | 9 |
| 26881291 | 10.1021/acs.jmedchem.5b01956 | DNA | 5 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 33979164 | 10.1021/acs.jmedchem.0c01104 | No relevant target | 2 |
| 33979164 | 10.1021/acs.jmedchem.0c01104 | Plasmodium falciparum | 2 |
| 29091431 | 10.1021/acs.jmedchem.7b01083 | Acetylcholinesterase | 2 |
| 28197313 | 10.1021/acsmedchemlett.6b00417 | Myeloperoxidase | 1 |
| 27347787 | 10.1021/acs.jmedchem.5b01871 | Unchecked | 1 |
| 28528081 | 10.1016/j.bmc.2017.04.024 | Liver carboxylesterase | 1 |
| 7381846 | 10.1021/jm00179a001 | Staphylococcus aureus | 1 |
| 26596892 | 10.1021/acs.jmedchem.5b01329 | No relevant target | 1 |
| 26596892 | 10.1021/acs.jmedchem.5b01329 | Alkaline phosphatase, tissue-nonspecific isozyme | 1 |
| 26541587 | 10.1016/j.bmc.2015.10.028 | Unchecked | 1 |
| 19822705 | 10.1128/aac.00583-09 | Pseudomonas putida | 1 |
| 7381846 | 10.1021/jm00179a001 | Streptococcus pyogenes | 1 |
| 7381846 | 10.1021/jm00179a001 | Pseudomonas aeruginosa | 1 |
Data from ChEMBL 36 via Core Engine