Assay Detail
Functional
CHEMBL5253255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic cytotoxicity against doxorubicin-sensitive human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 90 mins in presence of epirubicin by crystal violet staining assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255 | FORMALDEHYDE | -1.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255 | FORMALDEHYDE | IC50 | = | 500.0 | nM | 6.30 |