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Assay Detail

CHEMBL5254642

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of self-induced amyloid beta (unknown origin) aggregation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease.
Jalili-Baleh L, Babaei E, Abdpour S, Nasir Abbas Bukhari S, Foroumadi A, Ramazani A, Sharifzadeh M, Abdollahi M, Khoobi M.
Eur J Med Chem (2018) 152 : 570 -589
PubMed 29763806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.49 6.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5286183 1 6.08
CHEMBL5290033 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5286183 IC50 = 840.0 nM 6.08
CHEMBL5290033 IC50 = 13000.0 nM 4.89