Assay Detail
Functional
CHEMBL5254891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV LAI infected in human MT-2 cells assessed as inhibition of viral growth
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.26 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.80 |
| CHEMBL5284706 | — | — | 1 | 7.60 |
| CHEMBL5291125 | — | — | 1 | 7.54 |
| CHEMBL5288746 | — | — | 1 | 7.51 |
| CHEMBL5287201 | — | — | 1 | 7.50 |
| CHEMBL5267260 | — | — | 1 | 7.41 |
| CHEMBL5271223 | — | — | 1 | 7.03 |
| CHEMBL5280093 | — | — | 1 | 6.55 |
| CHEMBL5278603 | — | — | 1 | 6.37 |
| CHEMBL5268648 | — | — | 1 | 6.27 |
| CHEMBL5274743 | — | — | 1 | - |
| CHEMBL5287711 | — | — | 1 | - |
| CHEMBL5281851 | — | — | 1 | - |
| CHEMBL5266228 | — | — | 1 | - |
| CHEMBL5271083 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5284706 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5291125 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5288746 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5287201 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5267260 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5271223 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5280093 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5278603 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5268648 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5274743 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5287711 | — | IC50 | - | — | - | |
| CHEMBL5281851 | — | IC50 | - | — | - | |
| CHEMBL5266228 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5271083 | — | IC50 | > | 1000.0 | nM | - |