Assay Detail
Binding
CHEMBL5255776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 dependent IFNalpha-stimulated STAT3 phosphorylation in human Jurkat cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel N-(methyl-d<sub>3</sub>) pyridazine-3-carboxamide derivatives as TYK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.20 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273814 | — | — | 1 | 9.09 |
| CHEMBL5282623 | — | — | 1 | 9.00 |
| CHEMBL5268371 | — | — | 1 | 8.85 |
| CHEMBL5286565 | — | — | 1 | 8.74 |
| CHEMBL5267449 | — | — | 1 | 8.72 |
| CHEMBL5281991 | — | — | 1 | 8.60 |
| CHEMBL5270922 | — | — | 1 | 8.51 |
| CHEMBL5284638 | — | — | 1 | 8.49 |
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 8.34 |
| CHEMBL5279644 | — | — | 1 | 8.32 |
| CHEMBL5270823 | — | — | 1 | 8.24 |
| CHEMBL5278999 | — | — | 1 | 8.19 |
| CHEMBL5280466 | — | — | 1 | 8.08 |
| CHEMBL5285091 | — | — | 1 | 8.00 |
| CHEMBL5278635 | — | — | 1 | 7.96 |
| CHEMBL5273136 | — | — | 1 | 7.92 |
| CHEMBL5266772 | — | — | 1 | 7.89 |
| CHEMBL5269164 | — | — | 1 | 7.85 |
| CHEMBL5291007 | — | — | 1 | 7.62 |
| CHEMBL5282377 | — | — | 1 | 7.37 |
| CHEMBL5284232 | — | — | 1 | 7.29 |
| CHEMBL5289104 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273814 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL5282623 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5268371 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5286565 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5267449 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5281991 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5270922 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5284638 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5279644 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5270823 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5278999 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5280466 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5285091 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5278635 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5273136 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5266772 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5269164 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5291007 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5282377 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5284232 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5289104 | — | IC50 | = | 55.0 | nM | 7.26 |