Assay Detail
Binding
CHEMBL5255870
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Inhibition of SARS-CoV-2 main protease by FRET analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.69 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283942 | — | — | 1 | 9.70 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 8.51 |
| CHEMBL5173274 | — | — | 1 | 8.09 |
| CHEMBL5195325 | — | — | 1 | 7.82 |
| CHEMBL5274314 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283942 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4802135 | NIRMATRELVIR | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5173274 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5195325 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5274314 | — | IC50 | = | 46280.0 | nM | 4.33 |