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Assay Detail

CHEMBL5256555

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
Meanwell NA.
ACS Med Chem Lett (2023) 14 : 350 -361
PubMed 37077378 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 8.63 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5288294 1 9.52
CHEMBL5287953 1 9.25
CHEMBL5267961 1 9.22
CHEMBL135 ESTRADIOL 4.0 1 9.15
CHEMBL5272944 1 8.96
CHEMBL5290413 1 8.94
CHEMBL5268644 1 8.89
CHEMBL5274395 1 8.86
CHEMBL5290289 1 8.75
CHEMBL5276956 1 8.74
CHEMBL5265970 1 8.74
CHEMBL5283000 1 8.62
CHEMBL5267706 1 8.60
CHEMBL5287101 1 8.21
CHEMBL760 ANAGRELIDE 4.0 1 8.18
CHEMBL5288674 1 7.91
CHEMBL5286462 1 7.47
CHEMBL5274826 1 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5288294 EC50 = 0.3 nM 9.52
CHEMBL5287953 EC50 = 0.56 nM 9.25
CHEMBL5267961 EC50 = 0.6 nM 9.22
CHEMBL135 ESTRADIOL EC50 = 0.7 nM 9.15
CHEMBL5272944 EC50 = 1.09 nM 8.96
CHEMBL5290413 EC50 = 1.14 nM 8.94
CHEMBL5268644 EC50 = 1.3 nM 8.89
CHEMBL5274395 EC50 = 1.37 nM 8.86
CHEMBL5290289 EC50 = 1.77 nM 8.75
CHEMBL5276956 EC50 = 1.8 nM 8.74
CHEMBL5265970 EC50 = 1.8 nM 8.74
CHEMBL5283000 EC50 = 2.38 nM 8.62
CHEMBL5267706 EC50 = 2.53 nM 8.60
CHEMBL5287101 EC50 = 6.22 nM 8.21
CHEMBL760 ANAGRELIDE EC50 = 6.67 nM 8.18
CHEMBL5288674 EC50 = 12.3 nM 7.91
CHEMBL5286462 EC50 = 34.19 nM 7.47
CHEMBL5274826 EC50 = 42.88 nM 7.37