Assay Detail
Binding
CHEMBL5257300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 3CL protease using 2-aminobenzoyl-SVTLQSG-Tyr(NO2)-R as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.31 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468553 | — | — | 1 | 6.30 |
| CHEMBL5285762 | — | — | 1 | 5.37 |
| CHEMBL1339340 | — | — | 1 | 5.37 |
| CHEMBL495231 | — | — | 1 | 4.76 |
| CHEMBL523052 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468553 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5285762 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1339340 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL495231 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL523052 | — | IC50 | = | 18200.0 | nM | 4.74 |