Assay Detail
Binding
CHEMBL5257308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 3CL protease using (E-EDANS)RELNGGAPI(K-DABCYL)S EDANS as substrate by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.17 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1405735 | — | — | 1 | 5.66 |
| CHEMBL2311694 | — | — | 1 | 5.31 |
| CHEMBL2311695 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1405735 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2311694 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL2311695 | — | IC50 | = | 28100.0 | nM | 4.55 |