Assay Detail
Binding
CHEMBL5258348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human FGFR2 (400 to 821 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5286909 | — | — | 1 | 8.74 |
| CHEMBL5290074 | — | — | 1 | 8.28 |
| CHEMBL5181536 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5286909 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5290074 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5181536 | — | IC50 | = | 213.0 | nM | 6.67 |