Compound Detail
CHEMBL5286909
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Basic Information
| ChEMBL ID | CHEMBL5286909 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OXJWXQVCCWDQJS-DZGCQCFKSA-N |
8
Targets
10
Activities
1
Assay Types
12
PK Parameters
15
Publications
0
Known Names
Molecular Properties
378.4
MW (Da)
1.75
ALogP
7
HBA
1
HBD
95.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 10 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.82 | 8.76 | 1.5 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.74 | 8.18 | 1.8 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL4066 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.8 | 6.8 | 157.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.74 | 6.74 | 184.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.68 | 6.68 | 209.0 | 1 |
| Activin receptor type-1 CHEMBL5903 | IC50 | 6.32 | 6.32 | 477.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 2202.14 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 838.24 | ng.hr.mL-1 | Macaca fascicularis |
| CL | 16.67 | mL.min-1.kg-1 | Homo sapiens |
| CL | 23.33 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 11.67 | mL.min-1.kg-1 | Macaca fascicularis |
| Cmax | 5553.0 | nM | Rattus norvegicus |
| Cmax | 825.0 | nM | Macaca fascicularis |
| F | 100.0 | % | Rattus norvegicus |
| F | 20.0 | % | Macaca fascicularis |
| Fu | 0.11 | - | Homo sapiens |
| T1/2 | 6.6 | hr | Rattus norvegicus |
| T1/2 | 3.2 | hr | Macaca fascicularis |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine