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Assay Detail

CHEMBL5258371

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of KDR (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Nguyen MH, Ye HF, Xu Y, Truong L, Horsey A, Zhao P, Styduhar ED, Frascella M, Leffet L, Federowicz K, Behshad E, Wang A, Zhang K, Witten MR, Qi C, Jalluri R, Lai CT, Atasoylu O, Harris JJ, Hess R, Lin L, Zhang G, Covington M, Diamond S, Yao W, Vechorkin O.
ACS Med Chem Lett (2023) 14 : 312 -318
PubMed 36923909 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.74 6.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5286909 1 6.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5286909 IC50 = 184.0 nM 6.74